No. Pixxi display modules do not directly support RS485. However, you can use MOTG-RS485 or similar modules to connect a Pixxi display via RS485.
To connect a MOTG-RS485 to a Pixxi display, you can use a MOTG-Breadtooth and a.gen4-Breakout.
Using a MOTG-RS485 will require the only COM port of the Pixxi module which is also used in programming the display and a GPIO pin. Therefore, the MOTG-RS485 needs to be disconnected before uploading a project to the display module.